› 2cgr

X-ray diffraction
2.2Å resolution

LOCAL AND TRANSMITTED CONFORMATIONAL CHANGES ON COMPLEXATION OF AN ANTI-SWEETENER FAB

Released:
DOI: 10.2210/pdb2cgr/pdb
PDB entry 2cgr coloured by chain, front view.
PDB entry 2cgr coloured by chain, side view.
PDB entry 2cgr coloured by chain, top view.
Source organism: Mus musculus
Primary publication:
Local and transmitted conformational changes on complexation of an anti-sweetener Fab.
Guddat LW, Shan L, Anchin JM, Linthicum DS, Edmundson AB
J Mol Biol 236 247-74 (1994)
PMID: 7893280

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
Sequence domains:
Structure domains:

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-207572 (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Ig-like domain-containing protein Chain: L
Molecule details ›
Chain: L
Length: 219 amino acids
Theoretical weight: 24.12 KDa
Source organism: Mus musculus
Expression system: Not provided
UniProt:
  • Canonical: A2P1G9 (Residues: 1-219; Coverage: 100%)
Gene names: Igk-C, Igkc
Sequence domains:
Structure domains: Immunoglobulins
IGG2B-KAPPA NC6.8 FAB (HEAVY CHAIN) Chain: H
Molecule details ›
Chain: H
Length: 214 amino acids
Theoretical weight: 22.9 KDa
Source organism: Mus musculus
Expression system: Not provided
Structure domains: Immunoglobulins

Ligands and Environments

1 bound ligand:
Ligand GAS 1 x GAS
No modified residues

Experiments and Validation Details

Entry percentile scores
Spacegroup: P21212
Unit cell:
a: 131Å b: 114.1Å c: 37.3Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.214 0.214 not available
Expression system: Not provided

Quick links

Citations

9 review citations

Antibody-antigen interactions: new structures and new conformational changes.
Wilson et al. (1994)
8 more

21 mentions without citation

TarFisDock: a web server for identifying drug targets with docking approach.
Li et al. (2006)
20 more