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Crystal structure of human thioredoxin reductase 1

Source organism: Homo sapiens
Biochemical function: flavin adenine dinucleotide binding
Biological process: cell redox homeostasis
Cellular component: not assigned

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EC 1.8.1.9: Thioredoxin-disulfide reductase

Reaction catalysed:
Thioredoxin + NADP(+) = thioredoxin disulfide + NADPH
Systematic name:
Thioredoxin:NADP(+) oxidoreductase
Alternative Name(s):
  • NADP--thioredoxin reductase
  • NADPH(2):oxidized thioredoxin oxidoreductase
  • NADPH--thioredoxin reductase
  • NADPH:oxidized thioredoxin oxidoreductase
  • Thioredoxin reductase (NADPH)

EC 1.11.1.2: NADPH peroxidase

Reaction catalysed:
NADPH + H(2)O(2) = NADP(+) + 2 H(2)O
Systematic name:
NADPH:hydrogen-peroxide oxidoreductase
Alternative Name(s):
  • NADP peroxidase
  • Nicotinamide adenine dinucleotide phosphate peroxidase
  • TPN peroxidase
  • TPNH peroxidase
  • Triphosphopyridine nucleotide peroxidase

GO terms

Sequence families

Pfam Protein families (Pfam)
PF02852
Domain description: Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
Occurring in:
  1. Thioredoxin reductase 1, cytoplasmic
The deposited structure of PDB entry 2cfy contains 6 copies of Pfam domain PF02852 (Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain) in Thioredoxin reductase 1, cytoplasmic. Showing 1 copy in chain A.

PF07992
Domain description: Pyridine nucleotide-disulphide oxidoreductase
Occurring in:
  1. Thioredoxin reductase 1, cytoplasmic
The deposited structure of PDB entry 2cfy contains 6 copies of Pfam domain PF07992 (Pyridine nucleotide-disulphide oxidoreductase) in Thioredoxin reductase 1, cytoplasmic. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR036188
Domain description: FAD/NAD(P)-binding domain superfamily
Occurring in:
  1. Thioredoxin reductase 1, cytoplasmic
IPR016156
Domain description: FAD/NAD-linked reductase, dimerisation domain superfamily
Occurring in:
  1. Thioredoxin reductase 1, cytoplasmic
IPR004099
Domain description: Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain
Occurring in:
  1. Thioredoxin reductase 1, cytoplasmic
IPR012999
Domain description: Pyridine nucleotide-disulphide oxidoreductase, class I, active site
Occurring in:
  1. Thioredoxin reductase 1, cytoplasmic
IPR023753
Domain description: FAD/NAD(P)-binding domain
Occurring in:
  1. Thioredoxin reductase 1, cytoplasmic
IPR006338
Domain description: Thioredoxin/glutathione reductase selenoprotein
Occurring in:
  1. Thioredoxin reductase 1, cytoplasmic
IPR046952
Domain description: Glutathione reductase/thioredoxin reductase-like
Occurring in:
  1. Thioredoxin reductase 1, cytoplasmic
IPR001100
Domain description: Pyridine nucleotide-disulphide oxidoreductase, class I
Occurring in:
  1. Thioredoxin reductase 1, cytoplasmic

Structure domains

CATH CATH domains
3.50.50.60
Class: Alpha Beta
Architecture: 3-Layer(bba) Sandwich
Topology: FAD/NAD(P)-binding domain
Homology: FAD/NAD(P)-binding domain
Occurring in:
  1. Thioredoxin reductase 1, cytoplasmic
The deposited structure of PDB entry 2cfy contains 12 copies of CATH domain 3.50.50.60 (FAD/NAD(P)-binding domain) in Thioredoxin reductase 1, cytoplasmic. Showing 2 copies in chain A.
3.30.390.30
Class: Alpha Beta
Architecture: 2-Layer Sandwich
Topology: Enolase-like; domain 1
Homology: Enolase-like; domain 1
Occurring in:
  1. Thioredoxin reductase 1, cytoplasmic
The deposited structure of PDB entry 2cfy contains 6 copies of CATH domain 3.30.390.30 (Enolase-like; domain 1) in Thioredoxin reductase 1, cytoplasmic. Showing 1 copy in chain A.

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