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thyroxine-binding globulin complex with thyroxine

X-ray diffraction
2.8Å resolution
PDB entry 2ceo coloured by chain, front view.
PDB entry 2ceo coloured by chain, side view.
PDB entry 2ceo coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
monomeric (preferred)
Entry contents: 1 distinct polypeptide molecule

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Thyroxine-binding globulin
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Multimeric state: monomeric
Accessible surface area: 16731.66 Å2
Buried surface area: 1102.35 Å2
Dissociation area: 428.19 Å2
Dissociation energy (ΔGdiss): -7.32 kcal/mol
Dissociation entropy (TΔSdiss): 6.01 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138702
Assembly 2
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Assembly Name: Thyroxine-binding globulin
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Multimeric state: monomeric
Accessible surface area: 16680.4 Å2
Buried surface area: 1093.71 Å2
Dissociation area: 427.76 Å2
Dissociation energy (ΔGdiss): -7.39 kcal/mol
Dissociation entropy (TΔSdiss): 6.01 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-138702

Macromolecules

Thyroxine-binding globulin
Chains: A, B
Length: 379 amino acids
Theoretical weight: 42.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P05543 (Residues: 37-415; Coverage: 96%)
Gene names: SERPINA7, TBG
Pfam: Serpin (serine protease inhibitor)
InterPro:
CATH:
Thyroxine-binding globulin in PDB entry 2ceo, assembly 1, front view.
Thyroxine-binding globulin in PDB entry 2ceo, assembly 1, side view.
Thyroxine-binding globulin in PDB entry 2ceo, assembly 1, top view.
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