› 2cb8

X-ray diffraction
1.4Å resolution

High resolution crystal structure of liganded human L-ACBP

Released:
DOI: 10.2210/pdb2cb8/pdb
PDB entry 2cb8 coloured by chain, front view.
PDB entry 2cb8 coloured by chain, side view.
PDB entry 2cb8 coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
High resolution crystal structures of unliganded and liganded human liver ACBP reveal a new mode of binding for the acyl-CoA ligand.
Taskinen JP, van Aalten DM, Knudsen J, Wierenga RK
Proteins 66 229-38 (2007)
PMID: 17044054

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-139377 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Acyl-CoA-binding protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 87 amino acids
Theoretical weight: 10.06 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P07108 (Residues: 1-87; Coverage: 100%)
Gene name: DBI
Sequence domains: Acyl CoA binding protein
Structure domains: Acyl-CoA Binding Protein

Ligands and Environments

4 bound ligands:
Ligand MYA 4 x MYA
Ligand ZN 8 x ZN
Ligand SO4 1 x SO4
Ligand MXE 1 x MXE
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-4
Spacegroup: I23
Unit cell:
a: 118.49Å b: 118.49Å c: 118.49Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.172 0.171 0.194
Expression system: Escherichia coli

Quick links

Citations

7 review citations

Acyl-coenzyme A binding domain containing 3 (ACBD3; PAP7; GCP60): an emerging signaling molecule.
Fan et al. (2010)
6 more

1 mention without citation

The dipeptidyl peptidase IV inhibitors vildagliptin and K-579 inhibit a phospholipase C: a case of promiscuous scaffolds in proteins.
Chakraborty et al. (2013)