› 2c9m

X-ray diffraction
3Å resolution

Structure of (SR) Calcium-ATPase in the Ca2E1 state solved in a P1 crystal form.

Released:
DOI: 10.2210/pdb2c9m/pdb
PDB entry 2c9m coloured by chain, front view.
PDB entry 2c9m coloured by chain, side view.
PDB entry 2c9m coloured by chain, top view.
Source organism: Oryctolagus cuniculus
Primary publication:
Modulatory and catalytic modes of ATP binding by the calcium pump.
Jensen AM, Sørensen TL, Olesen C, Møller JV, Nissen P
EMBO J 25 2305-14 (2006)
PMID: 16710301

Function and Biology Details

Reaction catalysed: 
ATP + H(2)O + Ca(2+)(Side 1) = ADP + phosphate + Ca(2+)(Side 2)
Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-137501 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 994 amino acids
Theoretical weight: 109.6 KDa
Source organism: Oryctolagus cuniculus
UniProt:
  • Canonical: P04191 (Residues: 1-993; Coverage: 99%)
Gene name: ATP2A1
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:
Ligand CA 7 x CA
Ligand K 2 x K
Ligand CL 2 x CL
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: BESSY BEAMLINE 14.1
Spacegroup: P1
Unit cell:
a: 64.948Å b: 81.276Å c: 131.006Å
α: 97.64° β: 99.94° γ: 95.22°
R-values:
R R work R free
0.266 0.266 0.317

Quick links

Citations

18 review citations

A structural overview of the plasma membrane Na+,K+-ATPase and H+-ATPase ion pumps.
Morth et al. (2011)
17 more

9 mentions without citation

Linking Biochemical and Structural States of SERCA: Achievements, Challenges, and New Opportunities.
Aguayo-Ortiz et al. (2020)
8 more