Structure analysis

Structure of Trypanosoma brucei pteridine reductase (PTR1) in ternary complex with cofactor and the antifolate methotrexate

X-ray diffraction
2.2Å resolution
Source organism: Trypanosoma brucei brucei
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule

Assemblies

Assembly 1 (preferred)
Download    3D Visualisation
Multimeric state: homo tetramer

Binding statistics and energies are not available for this assembly

Macromolecules

Chains: A, B, C, D
Length: 268 amino acids
Theoretical weight: 28.74 KDa
Source organism: Trypanosoma brucei brucei
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: O76290 (Residues: 1-268; Coverage: 100%)
Gene name: PTR1
Pfam:
InterPro:
CATH: NAD(P)-binding Rossmann-like Domain

Search similar proteins