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Functional Role of the Aromatic Cage in Human Monoamine Oxidase B: Structures and Catalytic Properties of Tyr435 Mutant Proteins

Source organism: Homo sapiens
Biochemical function: monoamine oxidase activity
Biological process: response to corticosterone
Cellular component: neuronal cell body

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EC 1.4.3.4: Monoamine oxidase

Reaction catalysed:
RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2)
Systematic name:
Amine:oxygen oxidoreductase (deaminating)
Alternative Name(s):
  • Adrenaline oxidase
  • Adrenaline oxidase
  • Amine oxidase
  • Amine oxidase (flavin-containing)
  • Amine:oxygen oxidoreductase (deaminating) (flavin-containing)
  • Epinephrine oxidase
  • MAO
  • MAO A
  • MAO B
  • MAO-A
  • MAO-B
  • Monoamine oxidase A
  • Monoamine oxidase B
  • Monoamine:O(2) oxidoreductase (deaminating)
  • Polyamine oxidase
  • Serotonin deaminase
  • Spermidine oxidase
  • Spermine oxidase
  • Tyraminase
  • Tyramine oxidase

EC 1.4.3.21: Primary-amine oxidase

Reaction catalysed:
RCH(2)NH(2) + H(2)O + O(2) = RCHO + NH(3) + H(2)O(2)
Systematic name:
Primary-amine:oxygen oxidoreductase (deaminating)
Alternative Name(s):
  • Amine oxidase
  • Amine oxidase (copper-containing)
  • Amine oxidase (pyridoxal containing)
  • Benzylamine oxidase
  • CAO
  • Copper amine oxidase
  • Cu-amine oxidase
  • Cu-containing amine oxidase
  • Diamine oxidase
  • Diamino oxhydrase
  • Histamine deaminase
  • Histamine oxidase
  • Monoamine oxidase
  • Plasma monoamine oxidase
  • Polyamine oxidase
  • SSAO
  • Semicarbazide-sensitive amine oxidase

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF01593
Domain description: Flavin containing amine oxidoreductase
Occurring in:
  1. Amine oxidase [flavin-containing] B
The deposited structure of PDB entry 2c73 contains 2 copies of Pfam domain PF01593 (Flavin containing amine oxidoreductase) in Amine oxidase [flavin-containing] B. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR001613
Domain description: Flavin amine oxidase
Occurring in:
  1. Amine oxidase [flavin-containing] B
IPR036188
Domain description: FAD/NAD(P)-binding domain superfamily
Occurring in:
  1. Amine oxidase [flavin-containing] B
IPR002937
Domain description: Amine oxidase
Occurring in:
  1. Amine oxidase [flavin-containing] B

Structure domains

CATH CATH domains
3.90.660.10
Class: Alpha Beta
Architecture: Alpha-Beta Complex
Topology: Polyamine Oxidase; Chain A, domain 2
Homology: Polyamine Oxidase; Chain A, domain 2
Occurring in:
  1. Amine oxidase [flavin-containing] B
The deposited structure of PDB entry 2c73 contains 2 copies of CATH domain 3.90.660.10 (Polyamine Oxidase; Chain A, domain 2) in Amine oxidase [flavin-containing] B. Showing 1 copy in chain A.
3.50.50.60
Class: Alpha Beta
Architecture: 3-Layer(bba) Sandwich
Topology: FAD/NAD(P)-binding domain
Homology: FAD/NAD(P)-binding domain
Occurring in:
  1. Amine oxidase [flavin-containing] B
The deposited structure of PDB entry 2c73 contains 2 copies of CATH domain 3.50.50.60 (FAD/NAD(P)-binding domain) in Amine oxidase [flavin-containing] B. Showing 1 copy in chain A.
1.10.405.10
Class: Mainly Alpha
Architecture: Orthogonal Bundle
Topology: Guanine Nucleotide Dissociation Inhibitor; domain 1
Homology: Guanine Nucleotide Dissociation Inhibitor, domain 1
Occurring in:
  1. Amine oxidase [flavin-containing] B
The deposited structure of PDB entry 2c73 contains 2 copies of CATH domain 1.10.405.10 (Guanine Nucleotide Dissociation Inhibitor; domain 1) in Amine oxidase [flavin-containing] B. Showing 1 copy in chain A.
SCOP SCOP annotations
51913
Class: Alpha and beta proteins (a/b)
Fold: FAD/NAD(P)-binding domain
Superfamily: FAD/NAD(P)-binding domain
Occurring in:
  1. Amine oxidase [flavin-containing] B
The deposited structure of PDB entry 2c73 contains 2 copies of SCOP domain 51913 (FAD-linked reductases, N-terminal domain) in Amine oxidase [flavin-containing] B. Showing 1 copy in chain A.
54394
Class: Alpha and beta proteins (a+b)
Fold: FAD-linked reductases, C-terminal domain
Superfamily: FAD-linked reductases, C-terminal domain
Occurring in:
  1. Amine oxidase [flavin-containing] B
The deposited structure of PDB entry 2c73 contains 2 copies of SCOP domain 54394 (L-aminoacid/polyamine oxidase) in Amine oxidase [flavin-containing] B. Showing 1 copy in chain A.

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