PDBe 2c47

X-ray diffraction
2.4Å resolution

Structure of casein kinase 1 gamma 2

Source organism: Homo sapiens
Entry authors: Bunkoczi G, Rellos P, Das S, Ugochukwu E, Fedorov O, Sobott F, Eswaran J, Amos A, Ball L, von Delft F, Bullock A, Debreczeni J, Turnbull A, Sundstrom M, Weigelt J, Arrowsmith C, Edwards A, Knapp S

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Casein kinase I isoform gamma-2 Chains: A, B, C, D
Molecule details ›
Chains: A, B, C, D
Length: 313 amino acids
Theoretical weight: 36.59 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
  • Canonical: P78368 (Residues: 43-353; Coverage: 75%)
Gene names: CK1G2, CSNK1G2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X10SA
Spacegroup: P212121
Unit cell:
a: 93.959Å b: 97.088Å c: 185.914Å
α: 90° β: 90° γ: 90°
R R work R free
0.211 0.208 0.257
Expression system: Escherichia coli BL21