PDBe 2c0l

X-ray diffraction
2.3Å resolution

TPR DOMAIN OF HUMAN PEX5P IN COMPLEX WITH HUMAN MSCP2

Released:

Function and Biology Details

Reaction catalysed:
3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanoyl-CoA + propanoyl-CoA = CoA + 3-alpha,7-alpha,12-alpha-trihydroxy-24-oxo-5-beta-cholestanoyl-CoA
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Peroxisomal targeting signal 1 receptor Chain: A
Molecule details ›
Chain: A
Length: 305 amino acids
Theoretical weight: 33.52 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P50542 (Residues: 335-639; Coverage: 48%)
Gene names: PEX5, PXR1
Sequence domains:
Structure domains: Serine Threonine Protein Phosphatase 5, Tetratricopeptide repeat
Non-specific lipid-transfer protein Chain: B
Molecule details ›
Chain: B
Length: 122 amino acids
Theoretical weight: 13.17 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P22307 (Residues: 426-547; Coverage: 22%)
Gene name: SCP2
Sequence domains: SCP-2 sterol transfer family
Structure domains: SCP2 sterol-binding domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: EMBL/DESY, HAMBURG BEAMLINE X13
Spacegroup: P212121
Unit cell:
a: 40.48Å b: 68.62Å c: 137.39Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.205 0.202 0.256
Expression system: Escherichia coli