PDBe 2bo9

X-ray diffraction
1.6Å resolution

Human carboxypeptidase A4 in complex with human latexin.

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Carboxypeptidase A4 Chains: A, C
Molecule details ›
Chains: A, C
Length: 308 amino acids
Theoretical weight: 34.56 KDa
Source organism: Homo sapiens
Expression system: Komagataella pastoris
UniProt:
  • Canonical: Q9UI42 (Residues: 114-421; Coverage: 76%)
Gene names: CPA3, CPA4, UNQ694/PRO1339
Sequence domains: Zinc carboxypeptidase
Structure domains: Zn peptidases
Latexin Chains: B, D
Molecule details ›
Chains: B, D
Length: 222 amino acids
Theoretical weight: 25.8 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q9BS40 (Residues: 1-222; Coverage: 100%)
Gene name: LXN
Sequence domains: Latexin
Structure domains: Nuclear Transport Factor 2; Chain: A,

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID23-1
Spacegroup: P21
Unit cell:
a: 78.922Å b: 96.651Å c: 92.358Å
α: 90° β: 99.6° γ: 90°
R-values:
R R work R free
0.15 0.149 0.176
Expression systems:
  • Komagataella pastoris
  • Escherichia coli BL21(DE3)