› 2bjj

X-ray diffraction
2.4Å resolution

Structure of recombinant human lactoferrin produced in the milk of transgenic cows

Released:
DOI: 10.2210/pdb2bjj/pdb
PDB entry 2bjj coloured by chain, front view.
PDB entry 2bjj coloured by chain, side view.
PDB entry 2bjj coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
The protein structure of recombinant human lactoferrin produced in the milk of transgenic cows closely matches the structure of human milk-derived lactoferrin.
Thomassen EA, van Veen HA, van Berkel PH, Nuijens JH, Abrahams JP
Transgenic Res 14 397-405 (2005)
PMID: 16201406

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-136228 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lactotransferrin Chain: X
Molecule details ›
Chain: X
Length: 692 amino acids
Theoretical weight: 76.43 KDa
Source organism: Homo sapiens
Expression system: Bos taurus
UniProt:
  • Canonical: P02788 (Residues: 21-710; Coverage: 100%)
Gene names: GIG12, LF, LTF
Sequence domains: Transferrin
Structure domains: Periplasmic binding protein-like II

Ligands and Environments

3 bound ligands:
Ligand FE 2 x FE
Ligand CO3 2 x CO3
Ligand NAG 2 x NAG
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ENRAF-NONIUS FR591
Spacegroup: P212121
Unit cell:
a: 55.941Å b: 97.379Å c: 156.297Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.184 0.181 0.231
Expression system: Bos taurus

Quick links

Citations

5 review citations

Lactoferrin's Anti-Cancer Properties: Safety, Selectivity, and Wide Range of Action.
Cutone et al. (2020)
4 more

4 mentions without citation

Time to Kill and Time to Heal: The Multifaceted Role of Lactoferrin and Lactoferricin in Host Defense.
Ohradanova-Repic et al. (2023)
3 more