Function and Biology Details
NTP + H(2)O = NDP + phosphate.
Autocatalytically cleaves itself from the polyprotein of the foot- and-mouth disease virus by hydrolysis of a Lys-|-Gly bond, but then cleaves host cell initiation factor eIF-4G at bonds -Gly-|-Arg- and -Lys-|-Arg-.
Selective cleavage of Gln-|-Gly bond in the poliovirus polyprotein. In other picornavirus reactions Glu may be substituted for Gln, and Ser or Thr for Gly.
Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).
- not assigned
Structure analysis Details
Length: 209 amino acids
Theoretical weight: 22.96 KDa
Source organism: Foot-and-mouth disease virus
Expression system: Escherichia coli
- Canonical: P03306 (Residues: 1650-1856; Coverage: 9%)
Structure domains: Trypsin-like serine proteases