2bhe › Citations

From the insoluble dye indirubin towards highly active, soluble CDK2-inhibitors.

Jautelat R, Brumby T, Schäfer M, Briem H, Eisenbrand G, Schwahn S, Krüger M, Lücking U, Prien O, Siemeister G
Chembiochem 6 531-40 (2005)
Cited: 38 times
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Articles - 2bhe mentioned but not cited (7)

  1. Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis. Scherr N, Honnappa S, Kunz G, Mueller P, Jayachandran R, Winkler F, Pieters J, Steinmetz MO. Proc. Natl. Acad. Sci. U.S.A. 104 12151-12156 (2007)
  2. Novel Inverse Binding Mode of Indirubin Derivatives Yields Improved Selectivity for DYRK Kinases. Myrianthopoulos V, Kritsanida M, Gaboriaud-Kolar N, Magiatis P, Ferandin Y, Durieu E, Lozach O, Cappel D, Soundararajan M, Filippakopoulos P, Sherman W, Knapp S, Meijer L, Mikros E, Skaltsounis AL. ACS Med Chem Lett 4 22-26 (2013)
  3. Wogonin protects glomerular podocytes by targeting Bcl-2-mediated autophagy and apoptosis in diabetic kidney disease. Liu XQ, Jiang L, Li YY, Huang YB, Hu XR, Zhu W, Wang X, Wu YG, Meng XM, Qi XM. Acta Pharmacol Sin 43 96-110 (2022)
  4. Biased Docking for Protein-Ligand Pose Prediction. Arcon JP, Turjanski AG, Martí MA, Forli S. Methods Mol Biol 2266 39-72 (2021)
  5. Novel [(N-alkyl-3-indolylmethylene)hydrazono]oxindoles arrest cell cycle and induce cell apoptosis by inhibiting CDK2 and Bcl-2: synthesis, biological evaluation and in silico studies. Al-Warhi T, Abo-Ashour MF, Almahli H, Alotaibi OJ, Al-Sanea MM, Al-Ansary GH, Ahmed HY, Elaasser MM, Eldehna WM, Abdel-Aziz HA. J Enzyme Inhib Med Chem 35 1300-1309 (2020)
  6. Quinazolin-4(3H)-one based potential multiple tyrosine kinase inhibitors with excellent cytotoxicity. Mirgany TO, Abdalla AN, Arifuzzaman M, Motiur Rahman AFM, Al-Salem HS. J Enzyme Inhib Med Chem 36 2055-2067 (2021)
  7. correction Correction for Scherr et al., Structural basis for the specific inhibition of protein kinase G, a virulence factor of Mycobacterium tuberculosis. Proc. Natl. Acad. Sci. U.S.A. 104 16388-16388 (2007)


Reviews citing this publication (6)

  1. Untangling tau hyperphosphorylation in drug design for neurodegenerative diseases. Mazanetz MP, Fischer PM. Nat Rev Drug Discov 6 464-479 (2007)
  2. Potential of plant-derived natural products in the treatment of leukemia and lymphoma. Lucas DM, Still PC, Pérez LB, Grever MR, Kinghorn AD. Curr Drug Targets 11 812-822 (2010)
  3. Indirubin and Indirubin Derivatives for Counteracting Proliferative Diseases. Blažević T, Heiss EH, Atanasov AG, Breuss JM, Dirsch VM, Uhrin P. Evid Based Complement Alternat Med 2015 654098 (2015)
  4. Indirubin derivatives: a patent review (2010 - present). Gaboriaud-Kolar N, Vougogiannopoulou K, Skaltsounis AL. Expert Opin Ther Pat 25 583-593 (2015)
  5. Synthesis and bioactivity of carbohydrate derivatives of indigo, its isomers and heteroanalogues. Karapetyan G, Chakrabarty K, Hein M, Langer P. ChemMedChem 6 25-37 (2011)
  6. The Fundamental Role of Oxime and Oxime Ether Moieties in Improving the Physicochemical and Anticancer Properties of Structurally Diverse Scaffolds. Fotie J, Matherne CM, Mather JB, Wroblewski JE, Johnson K, Boudreaux LG, Perez AA. Int J Mol Sci 24 16854 (2023)

Articles citing this publication (25)

  1. 7-Bromoindirubin-3'-oxime induces caspase-independent cell death. Ribas J, Bettayeb K, Ferandin Y, Knockaert M, Garrofé-Ochoa X, Totzke F, Schächtele C, Mester J, Polychronopoulos P, Magiatis P, Skaltsounis AL, Boix J, Meijer L. Oncogene 25 6304-6318 (2006)
  2. Indirubin-3'-monoxime inhibits autophosphorylation of FGFR1 and stimulates ERK1/2 activity via p38 MAPK. Zhen Y, Sørensen V, Jin Y, Suo Z, Wiedłocha A. Oncogene 26 6372-6385 (2007)
  3. Kinetics, in silico docking, molecular dynamics, and MM-GBSA binding studies on prototype indirubins, KT5720, and staurosporine as phosphorylase kinase ATP-binding site inhibitors: the role of water molecules examined. Hayes JM, Skamnaki VT, Archontis G, Lamprakis C, Sarrou J, Bischler N, Skaltsounis AL, Zographos SE, Oikonomakos NG. Proteins 79 703-719 (2011)
  4. Purified brominated indole derivatives from Dicathais orbita induce apoptosis and cell cycle arrest in colorectal cancer cell lines. Esmaeelian B, Benkendorff K, Johnston MR, Abbott CA. Mar Drugs 11 3802-3822 (2013)
  5. An indirubin derivative, E804, exhibits potent angiosuppressive activity. Chan YK, Kwok HH, Chan LS, Leung KS, Shi J, Mak NK, Wong RN, Yue PY. Biochem. Pharmacol. 83 598-607 (2012)
  6. From Chinese medicine to anticancer drugs. Bradbury J. Drug Discov. Today 10 1131-1132 (2005)
  7. Study of the inhibition of cyclin-dependent kinases with roscovitine and indirubin-3'-oxime from molecular dynamics simulations. Zhang B, Tan VB, Lim KM, Tay TE, Zhuang S. J Mol Model 13 79-89 (2007)
  8. Synthesis and pharmacological evaluation of dehydroabietic acid thiourea derivatives containing bisphosphonate moiety as an inducer of apoptosis. Huang X, Huang R, Liao Z, Pan Y, Gou S, Wang H. Eur J Med Chem 108 381-391 (2016)
  9. Bis-isatin hydrazones with novel linkers: Synthesis and biological evaluation as cytotoxic agents. Ibrahim HS, Abou-Seri SM, Ismail NSM, Elaasser MM, Aly MH, Abdel-Aziz HA. Eur J Med Chem 108 415-422 (2016)
  10. Indirubin-3'-monoxime promotes autophagic and apoptotic death in JM1 human acute lymphoblastic leukemia cells and K562 human chronic myelogenous leukemia cells. Lee MY, Liu YW, Chen MH, Wu JY, Ho HY, Wang QF, Chuang JJ. Oncol. Rep. 29 2072-2078 (2013)
  11. Substituted indolin-2-ones as p90 ribosomal S6 protein kinase 2 (RSK2) inhibitors: Molecular docking simulation and structure-activity relationship analysis. Zhong Y, Xue M, Zhao X, Yuan J, Liu X, Huang J, Zhao Z, Li H, Xu Y. Bioorg. Med. Chem. 21 1724-1734 (2013)
  12. Determination and pharmacokinetic study of indirubin in rat plasma by high-performance liquid chromatography. Deng XY, Zheng SN, Gao GH, Fan G, Li F. Phytomedicine 15 277-283 (2008)
  13. Discovery of novel indirubin-3'-monoxime derivatives as potent inhibitors against CDK2 and CDK9. Yan L, Lai F, Chen X, Xiao Z. Bioorg. Med. Chem. Lett. 25 2447-2451 (2015)
  14. Indirubin 3'-(O-oxiran-2-ylmethyl)oxime: a novel anticancer agent. Ichimaru Y, Saito H, Uchiyama T, Metori K, Tabata K, Suzuki T, Miyairi S. Bioorg. Med. Chem. Lett. 25 1403-1406 (2015)
  15. Synthesis and antiproliferative activity of selenoindirubins and selenoindirubin-N-glycosides. Erben F, Kleeblatt D, Sonneck M, Hein M, Feist H, Fahrenwaldt T, Fischer C, Matin A, Iqbal J, Plötz M, Eberle J, Langer P. Org. Biomol. Chem. 11 3963-3978 (2013)
  16. Evaluating the enthalpic contribution to ligand binding using QM calculations: effect of methodology on geometries and interaction energies. Gleeson D, Tehan B, Gleeson MP, Limtrakul J. Org. Biomol. Chem. 10 7053-7061 (2012)
  17. Design and evaluation of 3-aminopyrazolopyridinone kinase inhibitors inspired by the natural product indirubin. Smyth LA, Matthews TP, Collins I. Bioorg. Med. Chem. 19 3569-3578 (2011)
  18. Development and full validation of an UPLC-MS/MS method for the quantification of the plant-derived alkaloid indirubin in rat plasma. Jähne EA, Sampath C, Butterweck V, Hamburger M, Oufir M. J Pharm Biomed Anal 128 247-252 (2016)
  19. [Glycosides of hydroxylamine derivatives. I. phase transfer synthesis and study of isatine-3-oximes glucosaminides influence on bacterial luminescence]. Kur'ianov VO, Chupakhina TA, Shapovalova AA, Katsev AM, Chirva VIa. Bioorg Khim 37 259-268 (2011)
  20. 1,2-Redox Transpositions of Tertiary Amides. Shennan BDA, Sánchez-Alonso S, Rossini G, Dixon DJ. J Am Chem Soc 145 21745-21751 (2023)
  21. 25 years food chemistry and toxicology at the University of Kaiserslautern. Habermeyer M, Guth S, Eisenbrand G. Mol Nutr Food Res 52 810-814 (2008)
  22. Design, Synthesis and Preliminary Antimicrobial Evaluation of N-Alkyl Chain Tethered C-5 Functionalized Bis-Isatins. Singh A, Nisha, Bains T, Hahn HJ, Liu N, Tam C, Cheng LW, Kim J, Debnath A, Land KM, Kumar V. Medchemcomm 8 1982-1992 (2017)
  23. Our senior editors. Gerhard Eisenbrand: food chemistry and environmental toxicology. Eisenbrand G. Biotechnol J 1 135-136 (2006)
  24. Synthesis and antibacterial activity studies in vitro of indirubin-3'-monoximes. Yang FF, Shuai MS, Guan X, Zhang M, Zhang QQ, Fu XZ, Li ZQ, Wang DP, Zhou M, Yang YY, Liu T, He B, Zhao YL. RSC Adv 12 25068-25080 (2022)
  25. Water-soluble cationic derivatives of indirubin, the active anticancer component from Indigo naturalis. Ginzinger W, Egger A, Mühlgassner G, Arion VB, Jakupec MA, Galanski M, Berger W, Keppler BK. Chem. Biodivers. 9 2175-2185 (2012)


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