EC 1.1.1.49: Glucose-6-phosphate dehydrogenase (NADP(+))
Reaction catalysed:
D-glucose 6-phosphate + NADP(+) = 6-phospho-D-glucono-1,5-lactone + NADPH
Systematic name:
D-glucose-6-phosphate:NADP(+) 1-oxidoreductase
Alternative Name(s):
- 6-phosphoglucose dehydrogenase
- D-glucose 6-phosphate dehydrogenase
- Entner-Doudoroff enzyme
- G6PD
- G6PDH
- GPD
- Glucose 6-phosphate dehydrogenase (NADP)
- Glucose-6-phosphate 1-dehydrogenase
- Glucose-6-phosphate dehydrogenase
- NADP-dependent glucose 6-phosphate dehydrogenase
- NADP-glucose-6-phosphate dehydrogenase
- Zwischenferment
GO terms
Biochemical function:
Biological process:
- negative regulation of reactive oxygen species metabolic process
- positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
- negative regulation of cell growth involved in cardiac muscle cell development
- glucose 6-phosphate metabolic process
- ribose phosphate biosynthetic process
- response to ethanol
- regulation of neuron apoptotic process
- erythrocyte maturation
- cellular response to oxidative stress
- response to food
- substantia nigra development
- pentose biosynthetic process
- response to organic cyclic compound
- negative regulation of protein glutathionylation
- response to iron(III) ion
- pentose-phosphate shunt, oxidative branch
- glutathione metabolic process
- NADPH regeneration
- NADP metabolic process
- cholesterol biosynthetic process
- lipid metabolic process
- pentose-phosphate shunt
- glucose metabolic process
Cellular component:
Sequence families
Protein families (Pfam)
InterPro annotations
Structure domains
CATH domains
3.30.360.10
Class:
Alpha Beta
Architecture:
2-Layer Sandwich
Topology:
Dihydrodipicolinate Reductase; domain 2
Homology:
Dihydrodipicolinate Reductase; domain 2
Occurring in:
