PDBe 2be6

X-ray diffraction
2Å resolution

2.0 A crystal structure of the CaV1.2 IQ domain-Ca/CaM complex

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Calmodulin-2 Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 150 amino acids
Theoretical weight: 16.97 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P0DP24 (Residues: 1-149; Coverage: 100%)
Gene names: CALM2, CAM2, CAMB
Structure domains: EF-hand
Voltage-dependent L-type calcium channel subunit alpha-1C Chains: D, E, F
Molecule details ›
Chains: D, E, F
Length: 37 amino acids
Theoretical weight: 4.37 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q13936 (Residues: 1659-1692; Coverage: 2%)
Gene names: CACH2, CACN2, CACNA1C, CACNL1A1, CCHL1A1

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: P21
Unit cell:
a: 84.731Å b: 37.241Å c: 86.86Å
α: 90° β: 97.77° γ: 90°
R-values:
R R work R free
0.205 0.202 0.255
Expression system: Escherichia coli