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Crystal Structure of HLA-A*2402 Complexed with a telomerase peptide

X-ray diffraction
2.8Å resolution
PDB entry 2bck coloured by chain, front view.
PDB entry 2bck coloured by chain, side view.
PDB entry 2bck coloured by chain, top view.
Source organism: Homo sapiens
Assemblies composition:
hetero trimer (preferred)
hetero hexamer
Entry contents: 3 distinct polypeptide molecules

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Assemblies

Assembly 1
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Multimeric state: hetero trimer
Accessible surface area: 20364.89 Å2
Buried surface area: 5843.2 Å2
Dissociation area: 1,415.78 Å2
Dissociation energy (ΔGdiss): 8.02 kcal/mol
Dissociation entropy (TΔSdiss): 12.18 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127090
Assembly 2 (preferred)
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Multimeric state: hetero trimer
Accessible surface area: 20067.44 Å2
Buried surface area: 5434.18 Å2
Dissociation area: 907.35 Å2
Dissociation energy (ΔGdiss): 13.68 kcal/mol
Dissociation entropy (TΔSdiss): 7.43 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-127090
Assembly 3
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Assembly Name: Telomerase catalytic core complex
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Multimeric state: hetero hexamer
Accessible surface area: 38953.7 Å2
Buried surface area: 12756.02 Å2
Dissociation area: 749.2 Å2
Dissociation energy (ΔGdiss): 9.28 kcal/mol
Dissociation entropy (TΔSdiss): 14.06 kcal/mol
Symmetry number: 2
PDBe Complex ID: PDB-CPX-127092

Macromolecules

HLA class I histocompatibility antigen, A alpha chain
Chains: A, D
Length: 294 amino acids
Theoretical weight: 33.72 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P04439 (Residues: 25-299; Coverage: 81%)
Gene names: HLA-A, HLAA
Pfam:
InterPro:
CATH:
SCOP:
HLA class I histocompatibility antigen, A alpha chain in PDB entry 2bck, assembly 2, front view.
HLA class I histocompatibility antigen, A alpha chain in PDB entry 2bck, assembly 2, side view.
HLA class I histocompatibility antigen, A alpha chain in PDB entry 2bck, assembly 2, top view.
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Beta-2-microglobulin
Chains: B, E
Length: 100 amino acids
Theoretical weight: 11.88 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P61769 (Residues: 21-119; Coverage: 100%)
Gene names: B2M, CDABP0092, HDCMA22P
Pfam: Immunoglobulin C1-set domain
InterPro:
CATH: Immunoglobulins
SCOP: C1 set domains (antibody constant domain-like)
Beta-2-microglobulin in PDB entry 2bck, assembly 2, front view.
Beta-2-microglobulin in PDB entry 2bck, assembly 2, side view.
Beta-2-microglobulin in PDB entry 2bck, assembly 2, top view.
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Telomerase reverse transcriptase
Chains: C, F
Length: 9 amino acids
Theoretical weight: 1.03 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: O14746 (Residues: 461-469; Coverage: 1%)
Gene names: EST2, TCS1, TERT, TRT
Telomerase reverse transcriptase in PDB entry 2bck, assembly 2, front view.
Telomerase reverse transcriptase in PDB entry 2bck, assembly 2, side view.
Telomerase reverse transcriptase in PDB entry 2bck, assembly 2, top view.
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