PDBe 2b8w

X-ray diffraction
2.22Å resolution

Crystal-structure of the N-terminal Large GTPase Domain of human Guanylate Binding protein 1 (hGBP1) in complex with GMP/AlF4

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Guanylate-binding protein 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 328 amino acids
Theoretical weight: 37.08 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: P32455 (Residues: 1-317; Coverage: 54%)
Gene name: GBP1
Sequence domains: Guanylate-binding protein, N-terminal domain
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: P212121
Unit cell:
a: 149.617Å b: 101.927Å c: 54.121Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.193 0.19 0.233
Expression system: Escherichia coli BL21