PDBe 2b7a

X-ray diffraction
2Å resolution

The structural basis of Janus Kinase 2 inhibition by a potent and specific pan-Janus kinase inhibitor

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein kinase JAK2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 293 amino acids
Theoretical weight: 34.59 KDa
Source organism: Homo sapiens
Expression system: Spodoptera frugiperda
UniProt:
  • Canonical: O60674 (Residues: 840-1132; Coverage: 26%)
Gene name: JAK2
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU RU300
Spacegroup: P41
Unit cell:
a: 111.273Å b: 111.273Å c: 70.577Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.211 0.209 0.249
Expression system: Spodoptera frugiperda