PDBe 2b3o

X-ray diffraction
2.8Å resolution

Crystal structure of human tyrosine phosphatase SHP-1

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of human protein-tyrosine phosphatase SHP-1.
J. Biol. Chem. 278 6516-20 (2003)
PMID: 12482860

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Tyrosine-protein phosphatase non-receptor type 6 Chain: A
Molecule details ›
Chain: A
Length: 532 amino acids
Theoretical weight: 60.35 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P29350 (Residues: 1-532; Coverage: 89%)
Gene names: HCP, PTP1C, PTPN6
Sequence domains:
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: CHESS BEAMLINE F1
Spacegroup: P212121
Unit cell:
a: 44.736Å b: 100.404Å c: 149.475Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.25 0.233 0.296
Expression system: Escherichia coli