› 2b0r

X-ray diffraction
2.6Å resolution

Crystal Structure of Cyclase-Associated Protein from Cryptosporidium parvum

Released:
DOI: 10.2210/pdb2b0r/pdb
PDB entry 2b0r coloured by chain, front view.
PDB entry 2b0r coloured by chain, side view.
PDB entry 2b0r coloured by chain, top view.
Source organism: Cryptosporidium parvum
Primary publication:
Structure and function of a G-actin sequestering protein with a vital role in malaria oocyst development inside the mosquito vector.
Hliscs M, Sattler JM, Tempel W, Artz JD, Dong A, Hui R, Matuschewski K, Schüler H
J Biol Chem 285 11572-83 (2010)
PMID: 20083609

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-176927 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
C-CAP/cofactor C-like domain-containing protein Chains: A, B
Molecule details ›
Chains: A, B
Length: 202 amino acids
Theoretical weight: 22.49 KDa
Source organism: Cryptosporidium parvum
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5CS32 (Residues: 1-183; Coverage: 100%)
Gene name: cgd5_440
Sequence domains: Adenylate cyclase associated (CAP) C terminal
Structure domains: Pectate Lyase C-like

Ligands and Environments

1 bound ligand:
Ligand UNX 1 x UNX
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU FR-E
Spacegroup: P21
Unit cell:
a: 67.258Å b: 58.863Å c: 65.81Å
α: 90° β: 115.47° γ: 90°
R-values:
R R work R free
0.219 0.216 0.267
Expression system: Escherichia coli

Quick links

Citations

6 review citations

The role of cyclase-associated protein in regulating actin filament dynamics - more than a monomer-sequestration factor.
Ono S. (2013)
5 more

3 mentions without citation

The apicomplexan glideosome and adhesins - Structures and function.
Boucher et al. (2015)
2 more