› 2b0o

X-ray diffraction
2.06Å resolution

Crystal structure of UPLC1 GAP domain

Released:
DOI: 10.2210/pdb2b0o/pdb
PDB entry 2b0o coloured by chain, front view.
PDB entry 2b0o coloured by chain, side view.
PDB entry 2b0o coloured by chain, top view.
Source organism: Homo sapiens
Entry authors: Ismail S, Shen L, Arrowsmith C, Edwards A, Sundstrom M, Weigelt J, Bochkarev A, Park H, Structural Genomics Consortium (SGC)

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
  • not assigned
Sequence domains:

Structure analysis Details

Assemblies composition:
homo dimer (preferred)
homo tetramer
Assembly name:
PDBe Complex ID:
PDB-CPX-186225 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 3 Chains: E, F, G, H
Molecule details ›
Chains: E, F, G, H
Length: 301 amino acids
Theoretical weight: 32.79 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8TDY4 (Residues: 416-697; Coverage: 31%)
Gene names: ASAP3, DDEFL1, UPLC1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand ZN 4 x ZN
No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X29A
Spacegroup: P21
Unit cell:
a: 54.055Å b: 106.716Å c: 100.365Å
α: 90° β: 98.97° γ: 90°
R-values:
R R work R free
0.185 0.183 0.233
Expression system: Escherichia coli BL21(DE3)

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