Function and Biology

Crystal Structure of TNF-alpha with a small molecule inhibitor

Source organism: Homo sapiens
Biochemical function: tumor necrosis factor receptor binding
Biological process: immune response
Cellular component: membrane

GO terms

Biochemical function:
Biological process:
Cellular component:

Sequence family

Pfam Protein family (Pfam)
PF00229
Domain description: TNF(Tumour Necrosis Factor) family
Occurring in:
  1. Tumor necrosis factor, soluble form
1 copy of Pfam domain PF00229 (TNF(Tumour Necrosis Factor) family) in Tumor necrosis factor, soluble form in PDB 2az5.

InterPro InterPro annotations
IPR006053
Domain description: Tumour necrosis factor
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR002959
Domain description: Tumour necrosis factor alpha
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR006052
Domain description: Tumour necrosis factor domain
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR008983
Domain description: Tumour necrosis factor-like domain superfamily
Occurring in:
  1. Tumor necrosis factor, soluble form
IPR021184
Domain description: Tumour necrosis factor, conserved site
Occurring in:
  1. Tumor necrosis factor, soluble form

Structure domain

CATH CATH domain
2.60.120.40
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Jelly Rolls
Occurring in:
  1. Tumor necrosis factor, soluble form
1 copy of CATH domain 2.60.120.40 (Jelly Rolls) in Tumor necrosis factor, soluble form in PDB 2az5.
SCOP SCOP annotation
49843
Class: All beta proteins
Fold: TNF-like
Superfamily: TNF-like
Occurring in:
  1. Tumor necrosis factor, soluble form
1 copy of SCOP domain 49843 (TNF-like) in Tumor necrosis factor, soluble form in PDB 2az5.