Structure analysis

Crystal Structure of TNF-alpha with a small molecule inhibitor

X-ray diffraction
2.1Å resolution
Source organism: Homo sapiens
Assembly composition:
homo tetramer (preferred)
Entry contents: 1 distinct polypeptide molecule


Assembly 1 (preferred)
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Multimeric state: homo tetramer
Accessible surface area: 24600 Å2
Buried surface area: 6200 Å2
Dissociation area: 500 Å2
Dissociation energy (ΔGdiss): -11 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Interface energy (ΔGint): -31 kcal/mol
Symmetry number: 2


Chains: A, B, C, D
Length: 148 amino acids
Theoretical weight: 16.41 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P01375 (Residues: 86-233; Coverage: 64%)
Gene names: TNF, TNFA, TNFSF2
Pfam: TNF(Tumour Necrosis Factor) family
CATH: Jelly Rolls
SCOP: TNF-like

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