PDBe 2ath

X-ray diffraction
2.28Å resolution

Crystal structure of the ligand binding domain of human PPAR-gamma im complex with an agonist


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Peroxisome proliferator-activated receptor gamma Chains: A, B
Molecule details ›
Chains: A, B
Length: 271 amino acids
Theoretical weight: 31 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: P37231 (Residues: 235-505; Coverage: 54%)
Gene names: NR1C3, PPARG
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSRRC BEAMLINE BL17B2
Spacegroup: P21
Unit cell:
a: 55.78Å b: 88.523Å c: 57.565Å
α: 90° β: 90.43° γ: 90°
R R work R free
0.216 0.216 0.288
Expression system: Escherichia coli