PDBe 2as8

X-ray diffraction
1.95Å resolution

Crystal structure of mature and fully active Der p 1 allergen

Released:

Function and Biology Details

Reaction catalysed:
Broad endopeptidase specificity. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Peptidase 1 Chains: A, B
Molecule details ›
Chains: A, B
Length: 222 amino acids
Theoretical weight: 25.03 KDa
Source organism: Dermatophagoides pteronyssinus
Expression system: Komagataella pastoris
UniProt:
  • Canonical: P08176 (Residues: 99-320; Coverage: 74%)
Gene name: DERP1
Sequence domains: Papain family cysteine protease
Structure domains: Cysteine proteinases

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21212
Unit cell:
a: 75.12Å b: 78.43Å c: 83.774Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.185 0.252
Expression system: Komagataella pastoris