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Structure of the DNA binding domains of NFAT and FOXP2 bound specifically to DNA.

X-ray diffraction
2.7Å resolution
PDB entry 2as5 coloured by chain, front view.
PDB entry 2as5 coloured by chain, side view.
PDB entry 2as5 coloured by chain, top view.
Source organism: Homo sapiens
Assembly composition:
hetero tetramer (preferred)
Entry contents: 2 distinct polypeptide molecules
2 distinct DNA molecules

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Assemblies

Assembly 1 (preferred)
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Assembly Name: Forkhead box protein P2 and Nuclear factor of activated T-cells, cytoplasmic 2 and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 25507.16 Å2
Buried surface area: 6010.63 Å2
Dissociation area: 1,327.19 Å2
Dissociation energy (ΔGdiss): 9.79 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-115083
Assembly 2
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Assembly Name: Forkhead box protein P2 and Nuclear factor of activated T-cells, cytoplasmic 2 and DNA
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Multimeric state: hetero tetramer
Accessible surface area: 25782.29 Å2
Buried surface area: 5815.49 Å2
Dissociation area: 1,281.33 Å2
Dissociation energy (ΔGdiss): 9.82 kcal/mol
Dissociation entropy (TΔSdiss): 13 kcal/mol
Symmetry number: 1
PDBe Complex ID: PDB-CPX-115083

Macromolecules

Nuclear factor of activated T-cells, cytoplasmic 2
Chains: M, N
Length: 287 amino acids
Theoretical weight: 32.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q13469 (Residues: 392-678; Coverage: 31%)
Gene names: NFAT1, NFATC2, NFATP
Pfam:
InterPro:
CATH:
SCOP:
Nuclear factor of activated T-cells, cytoplasmic 2 in PDB entry 2as5, assembly 1, front view.
Nuclear factor of activated T-cells, cytoplasmic 2 in PDB entry 2as5, assembly 1, side view.
Nuclear factor of activated T-cells, cytoplasmic 2 in PDB entry 2as5, assembly 1, top view.
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Forkhead box protein P2
Chains: F, G
Length: 93 amino acids
Theoretical weight: 11.03 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: O15409 (Residues: 502-594; Coverage: 13%)
Gene names: CAGH44, FOXP2, TNRC10
Pfam: Forkhead domain
InterPro:
CATH: Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain
SCOP: Forkhead DNA-binding domain
Forkhead box protein P2 in PDB entry 2as5, assembly 1, front view.
Forkhead box protein P2 in PDB entry 2as5, assembly 1, side view.
Forkhead box protein P2 in PDB entry 2as5, assembly 1, top view.
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DNA chains A, C
Name: 5'-D(TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*GP*)-3'
Representative chains: A, C
Length: 21 nucleotides
Theoretical weight: 6.49 KDa
5'-D(TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*GP*)-3' in PDB entry 2as5, assembly 1, front view.
5'-D(TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*GP*)-3' in PDB entry 2as5, assembly 1, side view.
5'-D(TP*TP*AP*GP*GP*AP*AP*AP*AP*TP*TP*TP*GP*TP*TP*TP*CP*AP*TP*AP*GP*)-3' in PDB entry 2as5, assembly 1, top view.
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DNA chains B, D
Name: 5'-D(AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*TP*)-3'
Representative chains: B, D
Length: 21 nucleotides
Theoretical weight: 6.39 KDa
5'-D(AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*TP*)-3' in PDB entry 2as5, assembly 1, front view.
5'-D(AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*TP*)-3' in PDB entry 2as5, assembly 1, side view.
5'-D(AP*AP*CP*TP*AP*TP*GP*AP*AP*AP*CP*AP*AP*AP*TP*TP*TP*TP*CP*CP*TP*)-3' in PDB entry 2as5, assembly 1, top view.
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