PDBe 2arv

X-ray diffraction
2Å resolution

Structure of human Activin A


Function and Biology Details

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Inhibin beta A chain Chains: A, B
Molecule details ›
Chains: A, B
Length: 116 amino acids
Theoretical weight: 12.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P08476 (Residues: 311-426; Coverage: 29%)
Gene name: INHBA
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: I222
Unit cell:
a: 63.572Å b: 96.247Å c: 118.038Å
α: 90° β: 90° γ: 90°
R R work R free
0.218 0.216 0.259
Expression system: Escherichia coli BL21(DE3)