PDBe 2arp

X-ray diffraction
2Å resolution

Activin A in complex with Fs12 fragment of follistatin


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero tetramer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Follistatin Chain: F
Molecule details ›
Chain: F
Length: 152 amino acids
Theoretical weight: 16.59 KDa
Source organism: Rattus norvegicus
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P21674 (Residues: 93-241; Coverage: 47%)
Gene name: Fst
Sequence domains:
Structure domains: Wheat Germ Agglutinin (Isolectin 2); domain 1
Inhibin beta A chain Chain: A
Molecule details ›
Chain: A
Length: 116 amino acids
Theoretical weight: 12.99 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
  • Canonical: P08476 (Residues: 311-426; Coverage: 29%)
Gene name: INHBA
Sequence domains: Transforming growth factor beta like domain
Structure domains: Cystine-knot cytokines

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM14
Spacegroup: P21212
Unit cell:
a: 79.297Å b: 94.502Å c: 44.873Å
α: 90° β: 90° γ: 90°
R R work R free
0.202 0.202 0.254
Expression system: Escherichia coli BL21(DE3)