PDBe 2aoa

X-ray diffraction
1.99Å resolution

Crystal structures of a high-affinity macrocyclic peptide mimetic in complex with the Grb2 SH2 domain

Released:

Function and Biology Details

Biochemical function:
  • not assigned
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo dimer
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Growth factor receptor-bound protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 99 amino acids
Theoretical weight: 11.58 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P62993 (Residues: 55-153; Coverage: 46%)
Gene names: ASH, GRB2
Sequence domains: SH2 domain
Structure domains: SHC Adaptor Protein

Ligands and Environments

2 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: F222
Unit cell:
a: 88.173Å b: 102.659Å c: 107.24Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.249 0.246 0.307
Expression system: Escherichia coli