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Trypanosoma rangeli Sialidase in Complex with 2-Keto-3-deoxy-D-glycero-D-galacto-2,3-difluoro-nononic acid (2,3-difluoro-KDN)

Source organism: Trypanosoma rangeli
Biochemical function: exo-alpha-(2->8)-sialidase activity
Biological process: oligosaccharide catabolic process
Cellular component: intracellular membrane-bounded organelle

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EC 3.2.1.18: Exo-alpha-sialidase

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Systematic name:
Acetylneuraminyl hydrolase
Alternative Name(s):
  • Acetylneuraminidase
  • Alpha-neuraminidase
  • N-acylneuraminate glycohydrolase
  • Neuraminidase
  • Sialidase

GO terms

Sequence family

Pfam Protein family (Pfam)
PF13859
Domain description: BNR repeat-like domain
Occurring in:
  1. Sialidase domain-containing protein
The deposited structure of PDB entry 2ags contains 1 copy of Pfam domain PF13859 (BNR repeat-like domain) in Sialidase domain-containing protein. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR008377
Domain description: Trypanosome sialidase
Occurring in:
  1. Sialidase domain-containing protein
IPR013320
Domain description: Concanavalin A-like lectin/glucanase domain superfamily
Occurring in:
  1. Sialidase domain-containing protein
IPR011040
Domain description: Sialidase
Occurring in:
  1. Sialidase domain-containing protein
IPR026856
Domain description: Sialidase family
Occurring in:
  1. Sialidase domain-containing protein
IPR036278
Domain description: Sialidase superfamily
Occurring in:
  1. Sialidase domain-containing protein

Structure domains

CATH CATH domains
2.60.120.200
Class: Mainly Beta
Architecture: Sandwich
Topology: Jelly Rolls
Homology: Jelly Rolls
Occurring in:
  1. Sialidase domain-containing protein
The deposited structure of PDB entry 2ags contains 1 copy of CATH domain 2.60.120.200 (Jelly Rolls) in Sialidase domain-containing protein. Showing 1 copy in chain A.
2.120.10.10
Class: Mainly Beta
Architecture: 6 Propeller
Topology: Neuraminidase
Homology: Neuraminidase
Occurring in:
  1. Sialidase domain-containing protein
The deposited structure of PDB entry 2ags contains 1 copy of CATH domain 2.120.10.10 (Neuraminidase) in Sialidase domain-containing protein. Showing 1 copy in chain A.
SCOP SCOP annotations
82038
Class: All beta proteins
Fold: Concanavalin A-like lectins/glucanases
Superfamily: Concanavalin A-like lectins/glucanases
Occurring in:
  1. Sialidase domain-containing protein
The deposited structure of PDB entry 2ags contains 1 copy of SCOP domain 82038 (Trypanosoma sialidase, C-terminal domain) in Sialidase domain-containing protein. Showing 1 copy in chain A.
50940
Class: All beta proteins
Fold: 6-bladed beta-propeller
Superfamily: Sialidases
Occurring in:
  1. Sialidase domain-containing protein
The deposited structure of PDB entry 2ags contains 1 copy of SCOP domain 50940 (Sialidases (neuraminidases)) in Sialidase domain-containing protein. Showing 1 copy in chain A.

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