PDBe 2ag4

X-ray diffraction
1.8Å resolution

Crystal Structure Analysis of GM2-activator protein complexed with phosphatidylcholine

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Ganglioside GM2 activator Chains: A, B
Molecule details ›
Chains: A, B
Length: 164 amino acids
Theoretical weight: 17.83 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P17900 (Residues: 32-193; Coverage: 95%)
Gene name: GM2A
Sequence domains: ML domain
Structure domains: Ganglioside M2 (gm2) activator

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 22-ID
Spacegroup: P21
Unit cell:
a: 41.5Å b: 64.09Å c: 80.99Å
α: 90° β: 92.81° γ: 90°
R-values:
R R work R free
0.188 0.188 0.224
Expression system: Escherichia coli BL21(DE3)