PDBe 2aep

X-ray diffraction
2.1Å resolution

An epidemiologically significant epitope of a 1998 influenza virus neuraminidase forms a highly hydrated interface in the NA-antibody complex.

Released:

Function and Biology Details

Reaction catalysed:
Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
hetero 12-mer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Neuraminidase Chain: A
Molecule details ›
Chain: A
Length: 395 amino acids
Theoretical weight: 43.87 KDa
Source organism: Influenza A virus (A/Memphis/31/98(H3N2))
UniProt:
  • Canonical: Q9DL16 (Residues: 67-461; Coverage: 86%)
Gene name: NA
Sequence domains: Neuraminidase
Structure domains: Neuraminidase
Ig heavy chain Mem5 Chain: H
Molecule details ›
Chain: H
Length: 217 amino acids
Theoretical weight: 23.29 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P84751 (Residues: 1-217; Coverage: 92%)
Sequence domains:
Structure domains: Immunoglobulins
Ig kappa chain V region Mem5 Chain: L
Molecule details ›
Chain: L
Length: 214 amino acids
Theoretical weight: 23.78 KDa
Source organism: Mus musculus
UniProt:
  • Canonical: P84750 (Residues: 1-121; Coverage: 100%)
Sequence domains: Immunoglobulin V-set domain
Structure domains: Immunoglobulins

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: RIGAKU
Spacegroup: P4212
Unit cell:
a: 155.057Å b: 155.057Å c: 102.645Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.19 0.188 0.224