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Crystal Structure and Paratope Determination of 82D6A3, an Antithrombotic Antibody Directed Against the von Willebrand factor A3-Domain

Source organisms:
Biochemical function: antigen binding
Biological process: immunoglobulin mediated immune response
Cellular component: immunoglobulin complex

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GO terms

Sequence families

Pfam Protein families (Pfam)
PF07654
Domain description: Immunoglobulin C1-set domain
Occurring in:
  1. Ig heavy chain Mem5
The deposited structure of PDB entry 2adf contains 1 copy of Pfam domain PF07654 (Immunoglobulin C1-set domain) in Ig heavy chain Mem5. Showing 1 copy in chain B [auth H].

PF07686
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Ig heavy chain Mem5
The deposited structure of PDB entry 2adf contains 1 copy of Pfam domain PF07686 (Immunoglobulin V-set domain) in Ig heavy chain Mem5. Showing 1 copy in chain B [auth H].

PF00092
Domain description: von Willebrand factor type A domain
Occurring in:
  1. von Willebrand factor
The deposited structure of PDB entry 2adf contains 1 copy of Pfam domain PF00092 (von Willebrand factor type A domain) in von Willebrand factor. Showing 1 copy in chain A.

InterPro InterPro annotations
IPR003597
Domain description: Immunoglobulin C1-set
Occurring in:
  1. Ig heavy chain Mem5
  2. 82D6A3 IgG
IPR013106
Domain description: Immunoglobulin V-set domain
Occurring in:
  1. Ig heavy chain Mem5
  2. 82D6A3 IgG
IPR036179
Domain description: Immunoglobulin-like domain superfamily
Occurring in:
  1. Ig heavy chain Mem5
  2. 82D6A3 IgG
IPR013783
Domain description: Immunoglobulin-like fold
Occurring in:
  1. Ig heavy chain Mem5
  2. 82D6A3 IgG
IPR007110
Domain description: Immunoglobulin-like domain
Occurring in:
  1. Ig heavy chain Mem5
  2. 82D6A3 IgG
IPR003599
Domain description: Immunoglobulin subtype
Occurring in:
  1. Ig heavy chain Mem5
  2. 82D6A3 IgG
IPR002035
Domain description: von Willebrand factor, type A
Occurring in:
  1. von Willebrand factor
IPR036465
Domain description: von Willebrand factor A-like domain superfamily
Occurring in:
  1. von Willebrand factor
IPR003006
Domain description: Immunoglobulin/major histocompatibility complex, conserved site
Occurring in:
  1. 82D6A3 IgG

Structure domains

CATH CATH domains
2.60.40.10
Class: Mainly Beta
Architecture: Sandwich
Topology: Immunoglobulin-like
Homology: Immunoglobulins
Occurring in:
  1. Ig heavy chain Mem5
  2. 82D6A3 IgG
The deposited structure of PDB entry 2adf contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in Ig heavy chain Mem5. Showing 2 copies in chain B [auth H].
The deposited structure of PDB entry 2adf contains 2 copies of CATH domain 2.60.40.10 (Immunoglobulin-like) in 82D6A3 IgG. Showing 2 copies in chain C [auth L].
3.40.50.410
Class: Alpha Beta
Architecture: 3-Layer(aba) Sandwich
Topology: Rossmann fold
Homology: von Willebrand factor, type A domain
Occurring in:
  1. von Willebrand factor
The deposited structure of PDB entry 2adf contains 1 copy of CATH domain 3.40.50.410 (Rossmann fold) in von Willebrand factor. Showing 1 copy in chain A.
SCOP SCOP annotations
48942
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: Immunoglobulin
Occurring in:
  1. Ig heavy chain Mem5
  2. 82D6A3 IgG
The deposited structure of PDB entry 2adf contains 1 copy of SCOP domain 48942 (C1 set domains (antibody constant domain-like)) in Ig heavy chain Mem5. Showing 1 copy in chain B [auth H].
The deposited structure of PDB entry 2adf contains 1 copy of SCOP domain 48942 (C1 set domains (antibody constant domain-like)) in 82D6A3 IgG. Showing 1 copy in chain C [auth L].
48727
Class: All beta proteins
Fold: Immunoglobulin-like beta-sandwich
Superfamily: Immunoglobulin
Occurring in:
  1. 82D6A3 IgG
The deposited structure of PDB entry 2adf contains 1 copy of SCOP domain 48727 (V set domains (antibody variable domain-like)) in 82D6A3 IgG. Showing 1 copy in chain C [auth L].
53301
Class: Alpha and beta proteins (a/b)
Fold: vWA-like
Superfamily: vWA-like
Occurring in:
  1. von Willebrand factor
The deposited structure of PDB entry 2adf contains 1 copy of SCOP domain 53301 (Integrin A (or I) domain) in von Willebrand factor. Showing 1 copy in chain A.

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