PDBe 2acx

X-ray diffraction
2.6Å resolution

Crystal Structure of G protein coupled receptor kinase 6 bound to AMPPNP

Released:

Function and Biology Details

Reaction catalysed:
ATP + [G-protein-coupled receptor] = ADP + [G-protein-coupled receptor] phosphate. 
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
G protein-coupled receptor kinase 6 Chains: A, B
Molecule details ›
Chains: A, B
Length: 576 amino acids
Theoretical weight: 66.01 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: P43250 (Residues: 1-576; Coverage: 100%)
  • Best match: P43250-3 (Residues: 1-559)
Gene names: GPRK6, GRK6
Sequence domains:
Structure domains:

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ALS BEAMLINE 8.3.1
Spacegroup: C2
Unit cell:
a: 120.164Å b: 59.27Å c: 221.095Å
α: 90° β: 102.58° γ: 90°
R-values:
R R work R free
0.204 0.202 0.243
Expression system: Trichoplusia ni