PDBe 2ac5

X-ray diffraction
3.2Å resolution

Structure of human Mnk2 Kinase Domain mutant D228G

Released:

Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Biological process:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
MAP kinase-interacting serine/threonine-protein kinase 2 Chain: A
Molecule details ›
Chain: A
Length: 316 amino acids
Theoretical weight: 35.6 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: Q9HBH9 (Residues: 72-385; Coverage: 68%)
Gene names: GPRK7, MKNK2, MNK2
Sequence domains: Protein kinase domain
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P3221
Unit cell:
a: 104.646Å b: 104.646Å c: 73.363Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.306 0.238 0.306
Expression system: Escherichia coli BL21