PDBe 2abi

X-ray diffraction
2.33Å resolution

Crystal structure of the human mineralocorticoid receptor ligand-binding domain bound to deoxycorticosterone

Released:
Source organism: Homo sapiens
Entry authors: Huyet J, Pinon G-M, Rochel M, Mayer C, Rafestin-Oblin M-E, Fagart J

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mineralocorticoid receptor Chains: A, B, C
Molecule details ›
Chains: A, B, C
Length: 256 amino acids
Theoretical weight: 29.68 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P08235 (Residues: 731-984; Coverage: 26%)
Gene names: MCR, MLR, NR3C2
Sequence domains: Ligand-binding domain of nuclear hormone receptor
Structure domains: Retinoid X Receptor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE BM30A
Spacegroup: P31
Unit cell:
a: 119.77Å b: 119.77Å c: 41.5Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.228 0.207 0.264
Expression system: Escherichia coli