PDBe 2a5u

X-ray diffraction
2.7Å resolution

Crystal Structure of human PI3Kgamma complexed with AS605240

Released:

Function and Biology Details

Reactions catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate. 
ATP + a protein = ADP + a phosphoprotein. 
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform Chain: A

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 140.446Å b: 67.406Å c: 105.971Å
α: 90° β: 96.35° γ: 90°
R-values:
R R work R free
0.285 0.279 0.351
Expression system: Spodoptera frugiperda