› 2a5e

Solution NMR

SOLUTION NMR STRUCTURE OF TUMOR SUPPRESSOR P16INK4A, RESTRAINED MINIMIZED MEAN STRUCTURE

Released:
DOI: 10.2210/pdb2a5e/pdb
PDB entry 2a5e coloured by chain, front view.
PDB entry 2a5e coloured by chain, side view.
PDB entry 2a5e coloured by chain, top view.
Source organism: Homo sapiens
Primary publication:
Tumor suppressor p16INK4A: determination of solution structure and analyses of its interaction with cyclin-dependent kinase 4.
Byeon IJ, Li J, Ericson K, Selby TL, Tevelev A, Kim HJ, O'Maille P, Tsai MD
Mol Cell 1 421-31 (1998)
PMID: 9660926

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domain:
Structure domain:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-154865 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Cyclin-dependent kinase inhibitor 2A Chain: A
Molecule details ›
Chain: A
Length: 156 amino acids
Theoretical weight: 16.55 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: P42771 (Residues: 1-156; Coverage: 100%)
Gene names: CDKN2, CDKN2A, MTS1
Structure domains: Ankyrin repeat-containing domain

Ligands and Environments

No bound ligands
No modified residues

Experiments and Validation Details

Entry percentile scores
Refinement method: simulated annealing
Expression system: Escherichia coli BL21(DE3)

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Citations

18 review citations

The ankyrin repeat: a diversity of interactions on a common structural framework.
Sedgwick et al. (1999)
17 more

18 mentions without citation

Regulatory mechanisms of tumor suppressor P16(INK4A) and their relevance to cancer.
Li et al. (2011)
17 more