PDBe 2a4z

X-ray diffraction
2.9Å resolution

Crystal Structure of human PI3Kgamma complexed with AS604850

Released:

Function and Biology Details

Reactions catalysed:
ATP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4,5-trisphosphate. 
ATP + a protein = ADP + a phosphoprotein. 
Biochemical function:
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SLS BEAMLINE X06SA
Spacegroup: C2
Unit cell:
a: 142.352Å b: 67.648Å c: 106.39Å
α: 90° β: 95.77° γ: 90°
R-values:
R R work R free
0.264 0.257 0.352
Expression system: Spodoptera frugiperda