PDBe 2zej

X-ray diffraction
2Å resolution

Structure of the ROC domain from the Parkinson's disease-associated leucine-rich repeat kinase 2 reveals a dimeric GTPase


Function and Biology Details

Reaction catalysed:
ATP + a protein = ADP + a phosphoprotein
Biochemical function:
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Entry contents:
1 distinct polypeptide molecule
Leucine-rich repeat serine/threonine-protein kinase 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 184 amino acids
Theoretical weight: 21.42 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
  • Canonical: Q5S007 (Residues: 1333-1516; Coverage: 7%)
Gene names: LRRK2, PARK8
Sequence domains: Ras of Complex, Roc, domain of DAPkinase
Structure domains:

Ligands and Environments

2 bound ligands:

1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 19-ID
Spacegroup: P1
Unit cell:
a: 44.438Å b: 44.404Å c: 53.681Å
α: 81.51° β: 69° γ: 78.71°
R R work R free
0.202 0.199 0.253
Expression system: Escherichia coli