› 2zcw

X-ray diffraction
1.5Å resolution

Crystal Structure of TTHA1359, a Transcriptional Regulator, CRP/FNR family from Thermus thermophilus HB8

Released:
DOI: 10.2210/pdb2zcw/pdb
PDB entry 2zcw coloured by chain, front view.
PDB entry 2zcw coloured by chain, side view.
PDB entry 2zcw coloured by chain, top view.
Source organism: Thermus thermophilus
Primary publication:
Global gene expression mediated by Thermus thermophilus SdrP, a CRP/FNR family transcriptional regulator.
Agari Y, Kashihara A, Yokoyama S, Kuramitsu S, Shinkai A
Mol Microbiol 70 60-75 (2008)
PMID: 18699868

Function and Biology Details

Biochemical function:
Biological process:
Cellular component:
Sequence domains:

Structure analysis Details

Assembly composition:
homo dimer (preferred)
Assembly name:
PDBe Complex ID:
PDB-CPX-177964 (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Transcriptional regulator SdrP Chain: A
Molecule details ›
Chain: A
Length: 202 amino acids
Theoretical weight: 22.4 KDa
Source organism: Thermus thermophilus
Expression system: Escherichia coli
UniProt:
  • Canonical: Q5SIL0 (Residues: 1-202; Coverage: 100%)
Gene name: TTHA1359
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:
Ligand MPD 3 x MPD
1 modified residue:
Ligand MSE 1 x MSE

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL26B2
Spacegroup: P41212
Unit cell:
a: 54.05Å b: 54.05Å c: 147.718Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.221 0.221 0.232
Expression system: Escherichia coli

Quick links

Citations

2 review citations

Biological roles of cAMP: variations on a theme in the different kingdoms of life.
Gancedo JM. (2013)
1 more

3 mentions without citation

Structural insights into the mechanism of the allosteric transitions of Mycobacterium tuberculosis cAMP receptor protein.
Reddy et al. (2009)
2 more