PDBe 2z80

X-ray diffraction
1.8Å resolution

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide


Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Toll-like receptor 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 353 amino acids
Theoretical weight: 39.71 KDa
Source organism: Eptatretus burgeri
Expression system: Trichoplusia ni
  • Canonical: O60603 (Residues: 1-284; Coverage: 35%)
Gene names: TIL4, TLR2
Sequence domains: Leucine rich repeat
Structure domains: Ribonuclease Inhibitor

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID29
Spacegroup: P21
Unit cell:
a: 54.269Å b: 101.383Å c: 59.586Å
α: 90° β: 99.82° γ: 90°
R R work R free
0.22 0.22 0.254
Expression system: Trichoplusia ni