PDBe 2z7x

X-ray diffraction
2.1Å resolution

Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero trimer (preferred)
Entry contents:
3 distinct polypeptide molecules
Macromolecules (3 distinct):
Toll-like receptor 2 Chain: A
Molecule details ›
Chain: A
Length: 549 amino acids
Theoretical weight: 62.24 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O60603 (Residues: 27-506, 509-539, 540-544, 545-553; Coverage: 69%)
Gene names: TIL4, TLR2
Sequence domains: Leucine rich repeat
Structure domains: Ribonuclease Inhibitor
Toll-like receptor 1 Chain: B
Molecule details ›
Chain: B
Length: 520 amino acids
Theoretical weight: 59.37 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: Q15399 (Residues: 25-475, 478-495, 496-501, 502-539; Coverage: 67%)
Gene names: KIAA0012, TLR1
Sequence domains: Leucine rich repeat
Structure domains: Ribonuclease Inhibitor
Pam3CSK4 Chain: C
Molecule details ›
Chain: C
Length: 5 amino acids
Theoretical weight: 622 Da
Source organism: synthetic construct
Expression system: Not provided

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: P21212
Unit cell:
a: 200.303Å b: 120.14Å c: 74.12Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.244 0.244 0.27
Expression systems:
  • Trichoplusia ni
  • Not provided