PDBe 2z5x

X-ray diffraction
2.2Å resolution

Crystal Structure of Human Monoamine Oxidase A with Harmine


Function and Biology Details

Reaction catalysed:
RCH(2)NHR' + H(2)O + O(2) = RCHO + R'NH(2) + H(2)O(2)
Biochemical function:
Biological process:
Cellular component:

Structure analysis Details

Assemblies composition:
monomeric (preferred)
homo tetramer
Entry contents:
1 distinct polypeptide molecule
Amine oxidase [flavin-containing] A Chain: A
Molecule details ›
Chain: A
Length: 513 amino acids
Theoretical weight: 58.26 KDa
Source organism: Homo sapiens
Expression system: Saccharomyces cerevisiae
  • Canonical: P21397 (Residues: 12-524; Coverage: 97%)
Gene name: MAOA
Sequence domains: Flavin containing amine oxidoreductase
Structure domains:

Ligands and Environments

Cofactor: Ligand FAD 1 x FAD
3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL44XU
Spacegroup: C222
Unit cell:
a: 135.263Å b: 218.706Å c: 54.373Å
α: 90° β: 90° γ: 90°
R R work R free
0.204 0.201 0.255
Expression system: Saccharomyces cerevisiae