PDBe 2z5t

X-ray diffraction
2.3Å resolution

Molecular basis for the inhibition of p53 by Mdmx

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Protein Mdm4 Chains: M, N, O
Molecule details ›
Chains: M, N, O
Length: 140 amino acids
Theoretical weight: 15.66 KDa
Source organism: Danio rerio
Expression system: Escherichia coli
UniProt:
  • Canonical: Q7ZUW7 (Residues: 15-140; Coverage: 25%)
Gene names: mdm4, mdmx
Sequence domains: SWIB/MDM2 domain
Structure domains: SWIB/MDM2 domain
Cellular tumor antigen p53 Chains: P, Q, R
Molecule details ›
Chains: P, Q, R
Length: 15 amino acids
Theoretical weight: 1.81 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: P04637 (Residues: 15-29; Coverage: 4%)
Gene names: P53, TP53

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: MPG/DESY, HAMBURG BEAMLINE BW6
Spacegroup: P21
Unit cell:
a: 81.08Å b: 30.54Å c: 101.1Å
α: 90° β: 102.94° γ: 90°
R-values:
R R work R free
0.22 0.211 0.264
Expression systems:
  • Escherichia coli
  • Not provided