PDBe 2z3y

X-ray diffraction
2.25Å resolution

Crystal structure of Lysine-specific demethylase1

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of histone demethylase LSD1 and tranylcypromine at 2.25 A.
Biochem. Biophys. Res. Commun. 366 15-22 (2008)
PMID: 18039463

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Lysine-specific histone demethylase 1A Chain: A
Molecule details ›
Chain: A
Length: 662 amino acids
Theoretical weight: 73.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21
UniProt:
  • Canonical: O60341 (Residues: 172-833; Coverage: 78%)
Gene names: AOF2, KDM1, KDM1A, KIAA0601, LSD1
Sequence domains:
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: SPRING-8 BEAMLINE BL41XU
Spacegroup: P6122
Unit cell:
a: 185.742Å b: 185.742Å c: 108.725Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.218 0.218 0.255
Expression system: Escherichia coli BL21