PDBe 2yuk

Solution NMR

Solution structure of the HMG box of human Myeloid/lymphoid or mixed-lineage leukemia protein 3 homolog

Released:
Source organism: Homo sapiens
Entry authors: Abe H, Tochio N, Miyamoto K, Koshiba S, Harada T, Watanabe S, Kigawa T, Yokoyama S, RIKEN Structural Genomics/Proteomics Initiative (RSGI)

Function and Biology Details

Reaction catalysed:
S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]
Biological process:
  • not assigned
Cellular component:

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Histone-lysine N-methyltransferase 2C Chain: A
Molecule details ›
Chain: A
Length: 90 amino acids
Theoretical weight: 10.21 KDa
Source organism: Homo sapiens
Expression system: Not provided
UniProt:
  • Canonical: Q8NEZ4 (Residues: 1631-1713; Coverage: 2%)
Gene names: HALR, KIAA1506, KMT2C, MLL3
Structure domains: High mobility group box domain

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
Chemical shift assignment: 91%
Refinement method: torsion angle dynamics
Chemical shifts: BMR11160  
Expression system: Not provided