PDBe 2yt4

X-ray diffraction
2.6Å resolution

Crystal structure of human DGCR8 core

Released:
Source organism: Homo sapiens
Primary publication:
Crystal structure of human DGCR8 core.
Nat. Struct. Mol. Biol. 14 847-53 (2007)
PMID: 17704815

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Microprocessor complex subunit DGCR8 Chain: A
Molecule details ›
Chain: A
Length: 232 amino acids
Theoretical weight: 26.25 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli BL21(DE3)
UniProt:
  • Canonical: Q8WYQ5 (Residues: 493-720; Coverage: 30%)
Gene names: C22orf12, DGCR8, DGCRK6, LP4941
Sequence domains: Double-stranded RNA binding motif
Structure domains:

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: PAL/PLS BEAMLINE 4A
Spacegroup: C2
Unit cell:
a: 57.511Å b: 59.985Å c: 70.921Å
α: 90° β: 106.86° γ: 90°
R-values:
R R work R free
0.214 0.214 0.269
Expression system: Escherichia coli BL21(DE3)