PDBe 2yiy

X-ray diffraction
2.49Å resolution

Crystal structure of compound 8 bound to TAK1-TAB

Released:
Source organism: Homo sapiens
Entry authors: Brown DG, Phillips C

Function and Biology Details

Structure analysis Details

Assembly composition:
monomeric (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Mitogen-activated protein kinase kinase kinase 7; TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 Chain: A
Molecule details ›
Chain: A
Length: 307 amino acids
Theoretical weight: 34.78 KDa
Source organism: Homo sapiens
Expression system: Trichoplusia ni
UniProt:
  • Canonical: O43318 (Residues: 31-303; Coverage: 45%)
  • Canonical: Q15750 (Residues: 468-497; Coverage: 6%)
  • nullnull
Gene names: MAP3K7, MAP3K7IP1, TAB1, TAK1
Sequence domains: Protein tyrosine kinase
Structure domains:

Ligands and Environments

1 bound ligand:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: APS BEAMLINE 17-ID
Spacegroup: I222
Unit cell:
a: 58.401Å b: 133.422Å c: 145.769Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.191 0.188 0.245
Expression system: Trichoplusia ni