PDBe 2yin

X-ray diffraction
2.7Å resolution

STRUCTURE OF THE COMPLEX BETWEEN Dock2 AND Rac1.

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Dedicator of cytokinesis protein 2 Chains: A, B
Molecule details ›
Chains: A, B
Length: 436 amino acids
Theoretical weight: 51.65 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: Q92608 (Residues: 1192-1622; Coverage: 24%)
Gene names: DOCK2, KIAA0209
Structure domains:
Ras-related C3 botulinum toxin substrate 1 Chains: C, D
Molecule details ›
Chains: C, D
Length: 196 amino acids
Theoretical weight: 21.86 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P63000 (Residues: 1-177; Coverage: 92%)
Gene names: MIG5, RAC1, TC25
Structure domains: P-loop containing nucleotide triphosphate hydrolases

Ligands and Environments

No bound ligands

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: DIAMOND BEAMLINE I02
Spacegroup: P21
Unit cell:
a: 68.51Å b: 98.61Å c: 130.13Å
α: 90° β: 99.64° γ: 90°
R-values:
R R work R free
0.206 0.203 0.255
Expression system: Escherichia coli